Our findings suggest a specific pathological effect of HNE-aSyn on dopaminergicneurons.
2
Here we studied dopaminergicneurons derived from patients with idiopathic and familial PD.
3
Cocaine enhanced the levels of striatal dopamine produced by electrical stimulation of dopaminergicneurons.
4
Each was integrated into the host striatum and contained dense clusters of dopaminergicneurons.
5
Several people with Parkinson's disease have been treated with intrastriatal grafts of fetal dopaminergicneurons.
1
However, the mechanistic links between PARK2 mutations and dopaminergicneuron degeneration are unclear.
2
Different stem cells even yield two identical series of dopaminergicneuron types, but with unrelated sister neurons.
3
Patients with Parkinson's disease have reduced reward sensitivity related to dopaminergicneuron loss, which is associated with impairments in reinforcement learning.
4
What's more, the rate of neurogenesis is similar to the rate of dopaminergicneuron loss reported using a chronic, systemic inflammatory response mouse model.
5
Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergicneuron death may act together to increase the risk of PD considerably.